GO:0002315 biological_process marginal zone B cell differentiation
| PAG Title | GO:0002315 biological_process marginal zone B cell differentiation |
| PAG ID | TAX014174 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). |
| Species | Homo sapiens |
| nCoCo Score | 181 |
| Base PAG ID | TAX014174 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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